Article
Insights from a multicenter study on adult H3 K27M-mutated glioma: Surgical resection's limited influence on overall survival, ATRX as molecular prognosticator.
Neuro-oncology - 5 Aug 2024
Ryba Alice, Özdemir Zeynep, Nissimov Nitzan, Hönikl Lisa, Neidert Nicolas, Jakobs Martin, Kalasauskas Darius, Krigers Aleksandrs, Thomé Claudius, Freyschlag Christian F, Ringel Florian, Unterberg Andreas, Dao Trong Philip, Beck Jürgen, Heiland Dieter Henrik, Meyer Bernhard, Vajkoczy Peter, Onken Julia, Stummer Walter, Suero Molina Eric, Gempt Jens, Westphal Manfred, Schüller Ulrich, Mohme Malte
Abstract excerpt
BACKGROUND: H3 K27M-mutated gliomas were first described as a new grade 4 entity in the 2016 World Health Organization classification. Current studies have focused on its typical appearance in children and young adults, increasing the need to better understand the prognostic factors and impact of surgery on adults. Here, we report a multicentric study of this entity in adults. METHODS: We included molecularly...
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