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Prognostic Indicators for H3K27M-Mutant Diffuse Midline Glioma: A Population-Based Retrospective Surveillance, Epidemiology, and End Results Database Analysis.

World neurosurgery - 1 Oct 2023

Adhikari Srijan, Bhutada Abhishek S, Ladner Liliana, Cuoco Joshua A, Entwistle John J, Marvin Eric A, Rogers Cara M

Abstract excerpt

BACKGROUND: Diffuse midline glioma with histone H3K27M mutation (H3K27M DMG) is a recently recognized World Health Organization grade IV glioma with a dismal prognosis. Despite maximal treatment, this high-grade glioma exhibits an estimated median survival of 9-12 months. However, little is known with regards to prognostic risk factors for overall survival (OS) for patients with this malignant tumor. The aim of...

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PMID: 37423332
DOI: 10.1016/j.wneu.2023.07.001

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