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Article

Comparative analysis of clinical characteristics and prognostic factors in adult and pediatric patients with H3K27M-mutant diffuse midline glioma.

Neurosurgical review - 16 Mar 2026

Zhang Rui, Jiang Gaoyue, Peng Youheng, Ju Yan, Liu Yanhui, Mao Qing, Yang Yuan, Zeng Yunhui, Zhou Peizhi, Li Qiang, Yang Xiang, Zhang Yuekang, Ren Yanming

Abstract excerpt

H3K27M-mutant diffuse midline glioma (H3K27M-DMG) is a lethal brain tumor predominantly affecting children but increasingly recognized in adults. Emerging evidence suggests potential differences in clinical behavior and survival outcomes between pediatric and adult patients. However, comparative studies remain scarce, and the impact of age on disease progression and treatment response is poorly understood. We...

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Identifiers

PMID: 41838184
DOI: 10.1007/s10143-026-04217-w
PMCID: PMC12992444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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