Article
Breast and bowel cancers diagnosed in people 'too young to have cancer': A blueprint for research using family and twin studies.
Genetic epidemiology - 1 Dec 2024
Hopper John L, Li Shuai, MacInnis Robert J, Dowty James G, Nguyen Tuong L, Bui Minh, Dite Gillian S, Esser Vivienne F C, Ye Zhoufeng, Makalic Enes, Schmidt Daniel F, Goudey Benjamin, Alpen Karen, Kapuscinski Miroslaw, Win Aung Ko, Dugué Pierre-Antoine, Milne Roger L, Jayasekara Harindra, Brooks Jennifer D, Malta Sue, Calais-Ferreira Lucas, Campbell Alexander C, Young Jesse T, Nguyen-Dumont Tu, Sung Joohon, Giles Graham G, Buchanan Daniel, Winship Ingrid, Terry Mary Beth, Southey Melissa C, Jenkins Mark A
Abstract excerpt
Young breast and bowel cancers (e.g., those diagnosed before age 40 or 50 years) have far greater morbidity and mortality in terms of years of life lost, and are increasing in incidence, but have been less studied. For breast and bowel cancers, the familial relative risks, and therefore the familial variances in age-specific log(incidence), are much greater at younger ages, but little of these familial variances...
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