Article
Variance of age-specific log incidence decomposition (VALID): a unifying model of measured and unmeasured genetic and non-genetic risks.
International journal of epidemiology - 5 Oct 2023
Hopper John L, Dowty James G, Nguyen Tuong L, Li Shuai, Dite Gillian S, MacInnis Robert J, Makalic Enes, Schmidt Daniel F, Bui Minh, Stone Jennifer, Sung Joohon, Jenkins Mark A, Giles Graham G, Southey Melissa C, Mathews John D
Abstract excerpt
BACKGROUND: The extent to which known and unknown factors explain how much people of the same age differ in disease risk is fundamental to epidemiology. Risk factors can be correlated in relatives, so familial aspects of risk (genetic and non-genetic) must be considered. DEVELOPMENT: We present a unifying model (VALID) for variance in risk, with risk defined as log(incidence) or logit(cumulative incidence)....
Topics
- Female
- Humans
- Age Factors
- Breast Neoplasms
- Genetic Predisposition to Disease
- Incidence
- Risk Factors