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Article

Sex effects on DNA methylation affect discovery in epigenome-wide association study of schizophrenia.

Molecular psychiatry - 1 Aug 2024

Tesfaye Markos, Spindola Leticia M, Stavrum Anne-Kristin, Shadrin Alexey, Melle Ingrid, Andreassen Ole A, Le Hellard Stephanie

Abstract excerpt

Sex differences in the epidemiology and clinical characteristics of schizophrenia are well-known; however, the molecular mechanisms underlying these differences remain unclear. Further, the potential advantages of sex-stratified meta-analyses of epigenome-wide association studies (EWAS) of schizophrenia have not been investigated. Here, we performed sex-stratified EWAS meta-analyses to investigate whether sex...

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Identifiers

PMID: 38503926
DOI: 10.1038/s41380-024-02513-9
PMCID: PMC11412896

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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