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Genetic and chemical control of tuberculostearic acid production in Mycobacterium avium subspecies paratuberculosis.

Microbiology spectrum - 2 May 2024

Bannantine John P, Duffy Shannon C, Colombatti Olivieri María A, Behr Marcel A, Biet Franck, Price Neil P J

Abstract excerpt

Tuberculostearic acid (TBSA) is a fatty acid unique to mycobacteria and some corynebacteria and has been studied due to its diagnostic value, biofuel properties, and role in membrane dynamics. In this study, we demonstrate that TBSA production can be abrogated either by addition of pivalic acid to mycobacterial growth cultures or by a bfaA gene knockout encoding a flavin adenine dinucleotide (FAD)-binding...

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Bacterial Proteins
Cattle
Fatty Acids
Methyltransferases
Mycobacterium avium subsp. paratuberculosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Paratuberculosis

Polymorphism, Single Nucleotide

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PMID: 38501867
DOI: 10.1128/spectrum.00508-24
PMCID: PMC11064506

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