Article
Propionate prevents loss of the PDIM virulence lipid in Mycobacterium tuberculosis.
Nature microbiology - 1 Jun 2024
Mulholland Claire V, Wiggins Thomas J, Cui Jinhua, Vilchèze Catherine, Rajagopalan Saranathan, Shultis Michael W, Reyes-Fernández Esmeralda Z, Jacobs William R, Berney Michael
Abstract excerpt
Phthiocerol dimycocerosate (PDIM) is an essential virulence lipid of Mycobacterium tuberculosis. In vitro culturing rapidly selects for spontaneous PDIM-negative mutants that have attenuated virulence and increased cell wall permeability, thus impacting the relevance of experimental findings. PDIM loss can also reduce the efficacy of the BCG Pasteur vaccine. Here we show that vancomycin susceptibility can rapidly...
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