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Article

PTEN decreases NR2F1 expression to inhibit ciliogenesis during EGFRL858R-induced lung cancer progression.

Cell death & disease - 18 Mar 2024

Tran Thi Thanh Truc, Hung Jan-Jong

Abstract excerpt

Lung cancer is the major cause of death worldwide. Activation of oncogenes or inhibition of tumor suppressors causes cancer formation. Previous studies have indicated that PTEN, as a tumor suppressor, inhibits cancer formation. In this study, we studied the role of PTEN in EGFRL858R-induced lung cancer in vivo. Interestingly, loss of PTEN increased bronchial cell hyperplasia but decreased alveolar cell...

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Identifiers

PMID: 38499532
DOI: 10.1038/s41419-024-06610-z
PMCID: PMC10948910

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