Article
An ShRNA Based Genetic Screen Identified Sesn2 as a Potential Tumor Suppressor in Lung Cancer via Suppression of Akt-mTOR-p70S6K Signaling.
PloS one - 1 Jan 2015
Xu Hui, Sun Huiying, Zhang Haiyuan, Liu Jiawei, Fan Fangfang, Li Yilan, Ning Xuelian, Sun Yue, Dai Shaochun, Liu Baogang, Gao Min, Fu Songbin, Zhou Chunshui
Abstract excerpt
BACKGROUND: Lung cancer is emerging rapidly as the leading death cause in Chinese cancer patients. The causal factors for Chinese lung cancer development remain largely unclear. Here we employed an shRNA library-based loss-of-function screen in a genome-wide and unbiased manner to interrogate potential tumor suppressor candidates in the immortalized human lung epithelial cell line BEAS-2B. METHODS/RESULTS: Soft...
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