Article
Development of Kras mutant lung adenocarcinoma in mice with knockout of the airway lineage-specific gene Gprc5a.
International journal of cancer - 15 Oct 2017
Fujimoto Junya, Nunomura-Nakamura Sayuri, Liu Yihua, Lang Wenhua, McDowell Tina, Jakubek Yasminka, Ezzeddine Dalia, Kapere Ochieng Joshua, Petersen Jason, Davies Gareth, Fukuoka Junya, Wistuba Ignacio I, Ehli Erik, Fowler Jerry, Scheet Paul, Kadara Humam
Abstract excerpt
Despite the urgency for prevention and treatment of lung adenocarcinoma (LUAD), we still do not know drivers in pathogenesis of the disease. Earlier work revealed that mice with knockout of the G-protein coupled receptor Gprc5a develop late onset lung tumors including LUADs. Here, we sought to further probe the impact of Gprc5a expression on LUAD pathogenesis. We first surveyed GPRC5A expression in human tissues...
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