Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural basis of MPL activation by thrombopoietin

16 Jul 2024

Abstract excerpt

Myeloproliferative leukemia protein (MPL), also known as thrombopoietin (TPO) receptor, is a class I cytokine receptor that is expressed on hematopoietic progenitors, promoting growth and differentiation toward the megakaryocyte lineage and is critical for normal platelet production. Mutations in MPL, TPO, or Janus kinase 2 (JAK2) have been implicated in multiple diseases from congenital thrombocytopenias to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Lymphocytic Leukemia Research
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment
Share to Platelet Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40766813
DOI: 10.1016/j.bvth.2024.100018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural basis of MPL activation by thrombopoietinPMID 40766813Read ↗

Effects of clinically relevant MPL mutations in the transmembrane domain revealed at the atomic level through computational modeling.Semantic proximity Read ↗

Thrombopoietin Receptor MPL in Hematopoiesis and Myeloproliferative Neoplasms: Physiological Roles and Pathogenic Mechanisms.Semantic proximity Read ↗

Modulation of human thrombopoietin receptor conformations uncouples JAK2 V617F-driven activation from cytokine-induced stimulation.Semantic proximity Read ↗

The MPL mutation.Semantic proximity Read ↗

Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease.Semantic proximity Read ↗

The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasmSemantic proximity Read ↗

The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated CalreticulinSemantic proximity Read ↗

Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning.Semantic proximity Read ↗

In silico analysis of Missense Variants in Human MPL Gene Associated with Essential ThrombocythemiaSemantic proximity Read ↗

Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia.Semantic proximity Read ↗

In and out: Traffic and dynamics of thrombopoietin receptor.Semantic proximity Read ↗

Thrombopoietin: the Primary Regulator of Megakaryocyte and Platelet ProductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.