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Article

Hematopoietic Deficiencies in c‐mpl and TPO Knockout Mice

1 Jan 1998

Abstract excerpt

Thrombopoietin (TPO) is the primary regulatory of megakaryocyte (Meg) and platelet production. Its receptor, c-mpl, is a member of the cytokine receptor superfamily. Major insight into the physiological role of this receptor/ligand pair came from the study of mice carrying disrupted alleles of these two genes. Both TPO and c-mpl knockout mice are viable, but have a 90% reduction in platelet counts. Their...

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Identifiers

PMID: 9474742
DOI: 10.1002/stem.160001

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Related research

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Hematopoietic Deficiencies in c‐mpl and TPO Knockout MicePMID 9474742Read ↗

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-MplSemantic proximity Read ↗

Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin.Semantic proximity Read ↗

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferationSemantic proximity Read ↗

The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor.Semantic proximity Read ↗

Thrombopoietin: the Primary Regulator of Megakaryocyte and Platelet ProductionSemantic proximity Read ↗

The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasmSemantic proximity Read ↗

Studies of the c-Mpl thrombopoietin receptor through gene disruption and activation.Semantic proximity Read ↗

Thrombopoietin is essential for the maintenance of normal hematopoiesis in humans: development of aplastic anemia in patients with congenital amegakaryocytic thrombocytopenia.Semantic proximity Read ↗

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An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.Semantic proximity Read ↗

Mathematical modelling of megakaryopoiesis in Mpl-deficient and continuously thrombopoietin-stimulated mice points to an unknown control mechanismSemantic proximity Read ↗

Anomalous megakaryocytopoiesis in mice with mutations in the c-Myb gene.Semantic proximity Read ↗

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