Article
Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin.
The Journal of experimental medicine - 1 Feb 1996
de Sauvage F J, Carver-Moore K, Luoh S M, Ryan A, Dowd M, Eaton D L, Moore M W
Abstract excerpt
Thrombopoietin (TPO) has recently been cloned and shown to regulate megakaryocyte and platelet production by activating the cytokine receptor c-mpl. To determine whether TPO is the only ligand for c-mpl and the major regulator of megakaryocytopoiesis, TPO deficient mice were generated by gene tar...
Topics
- Animals
- Base Sequence
- Blood Cell Count
- Blood Platelets
- Blotting, Northern
- Gene Dosage
- Genotype
- Interleukin-3
- Megakaryocytes
- Mice
- Molecular Sequence Data
- Mutagenesis
- Ploidies
- Polymerase Chain Reaction
- Recombination, Genetic
- Stem Cell Factor
- Stem Cells
- Thrombopoietin