The mutational load and a T-cell inflamed tumour phenotype identify ovarian cancer patients rendering tumour-reactive T cells from PD-1+ tumour-infiltrating lymphocytes.

doi:10.1038/s41416-020-01218-4

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Article

The mutational load and a T-cell inflamed tumour phenotype identify ovarian cancer patients rendering tumour-reactive T cells from PD-1+ tumour-infiltrating lymphocytes.

British journal of cancer - 1 Mar 2021

Salas-Benito Diego, Conde Enrique, Tamayo-Uria Ibon, Mancheño Uxua, Elizalde Edurne, Garcia-Ros David, Aramendia Jose M, Muruzabal Juan C, Alcaide Julia, Guillen-Grima Francisco, Minguez Jose A, Amores-Tirado Jose, Gonzalez-Martin Antonio, Sarobe Pablo, Lasarte Juan J, Ponz-Sarvise Mariano, De Andrea Carlos E, Hervas-Stubbs Sandra

Abstract excerpt

BACKGROUND: Adoptive immunotherapy with tumour-infiltrating lymphocytes (TIL) may benefit from the use of selective markers, such as PD-1, for tumour-specific T-cell enrichment, and the identification of predictive factors that help identify those patients capable of rendering tumour-reactive TILs. We have investigated this in ovarian cancer (OC) patients as candidates for TIL therapy implementation. METHODS:...

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Identifiers

PMID: 33402737
DOI: 10.1038/s41416-020-01218-4
PMCID: PMC7961070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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