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UMP‐CMP kinase 2 inhibits ZIKV replication through activation of type I IFN signaling pathway

1 Mar 2024

Abstract excerpt

Cytidine/uridine monophosphate kinase 2 (UMP-CMP kinase 2, CMPK2) has been reported as an antiviral interferon-stimulated gene (ISG). We previously observed that the expression of CMPK2 was significantly upregulated after Zika Virus (ZIKV) infection in A549 cells. However, the association and the underlying mechanisms between CMPK2 induction and ZIKV replication remain to be determined. We investigated the...

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PMID: 38483048
DOI: 10.1002/jmv.29533

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