Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell transcriptome analysis reveals SOX9 mutation-driven tumor stemness and microenvironment remodeling through the COL1A1-CD44 axis in colorectal cancer.

BMC cancer - 30 May 2026

Pan Yuwei, Xiang Xuelian, Li Junfeng, Ge Yinggang, Liang Xiaoyan

Abstract excerpt

Colorectal cancer (CRC) exhibits substantial interpatient heterogeneity and is driven by intricate crosstalk between tumor-intrinsic mutations and the tumor microenvironment (TME), yet the mechanisms by which specific genetic alterations remodel the TME and regulate tumor stemness remain elusive. The SRY-box transcription factor 9 (SOX9) is a key regulator of intestinal homeostasis, with mutations implicated in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Collagen Type I
Share to Collagen Type I, alpha 1 Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hyaluronan Receptors

Share to Neoplastic Stem Cells

Share to Single-Cell Analysis

Share to Single-Cell Gene Expression Analysis

Share to SOX9 Transcription Factor

Share to Tumor Microenvironment

Source

Open in PubMed Open full text

Identifiers

PMID: 42218401
DOI: 10.1186/s12885-026-16248-z
PMCID: PMC13430886

Genes

SOX9
CD44
COL1A1
SRY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell transcriptome analysis reveals SOX9 mutation-driven tumor stemness and microenvironment remodeling through the COL1A1-CD44 axis in colorectal cancer.PMID 42218401Read ↗

Colorectal Cancer Stem Cell Subtypes Orchestrate Distinct Tumor MicroenvironmentsSemantic proximity Read ↗

Identification of Colorectal Cancer Cell Stemness from Single-Cell RNA SequencingSemantic proximity Read ↗

Tracing the stemness and malignant transition in a heritable colorectal cancer Lynch Syndrome by single-cell RNA-seq analysisSemantic proximity Read ↗

Integration of single-cell sequencing and bulk RNA-seq to identify and develop a prognostic signature related to colorectal cancer stem cellsSemantic proximity Read ↗

SOX9-regulated cell plasticity in colorectal metastasis is attenuated by rapamycinSemantic proximity Read ↗

Single-cell sequencing reveals CD133+CD44--originating evolution and novel stemness related variants in human colorectal cancer.Semantic proximity Read ↗

Colorectal Cancer Stem Cell States Uncovered by Simultaneous Single‐Cell Analysis of Transcriptome and TelomeresSemantic proximity Read ↗

Redefining colorectal cancer classification and clinical stratification through a single-cell atlasSemantic proximity Read ↗

Single-cell and bulk transcriptome sequencing identifies two epithelial tumor cell states and refines the consensus molecular classification of colorectal cancerSemantic proximity Read ↗

Clinical Implications of Colorectal Cancer Stem Cells in the Age of Single-Cell Omics and Targeted TherapiesSemantic proximity Read ↗

Portrait of Cancer Stem Cells on Colorectal Cancer: Molecular Biomarkers, Signaling Pathways and miRNAomeSemantic proximity Read ↗

Single-Cell Transcriptomics Reveals Cellular Heterogeneity and Drivers in Serrated Pathway-Driven Colorectal Cancer ProgressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.