Article
Narcolepsy is strongly associated with the T-cell receptor alpha locus.
Nature genetics - 1 Jun 2009
Hallmayer Joachim, Faraco Juliette, Lin Ling, Hesselson Stephanie, Winkelmann Juliane, Kawashima Minae, Mayer Geert, Plazzi Giuseppe, Nevsimalova Sona, Bourgin Patrice, Hong Seung-Chul, Hong Sheng Seung-Chul, Honda Yutaka, Honda Makoto, Högl Birgit, Longstreth William T, Montplaisir Jacques, Kemlink David, Einen Mali, Chen Justin, Musone Stacy L, Akana Matthew, Miyagawa Taku, Duan Jubao, Desautels Alex, Erhardt Christine, Hesla Per Egil, Poli Francesca, Frauscher Birgit, Jeong Jong-Hyun, Lee Sung-Pil, Ton Thanh G N, Kvale Mark, Kolesar Libor, Dobrovolná Marie, Nepom Gerald T, Salomon Dan, Wichmann H-Erich, Rouleau Guy A, Gieger Christian, Levinson Douglas F, Gejman Pablo V, Meitinger Thomas, Young Terry, Peppard Paul, Tokunaga Katsushi, Kwok Pui-Yan, Risch Neil, Mignot Emmanuel
Abstract excerpt
Narcolepsy with cataplexy, characterized by sleepiness and rapid onset into REM sleep, affects 1 in 2,000 individuals. Narcolepsy was first shown to be tightly associated with HLA-DR2 (ref. 3) and later sublocalized to DQB1*0602 (ref. 4). Following studies in dogs and mice, a 95% loss of hypocretin-producing cells in postmortem hypothalami from narcoleptic individuals was reported. Using genome-wide association...
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