Fragmentation patterns of cell-free DNA and somatic mutations in the urine of metastatic breast cancer patients.

doi:10.4103/jcrt.jcrt_1359_23

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Article

Fragmentation patterns of cell-free DNA and somatic mutations in the urine of metastatic breast cancer patients.

Journal of cancer research and therapeutics - 1 Apr 2024

Lin Shaoyan, Wang Shusen, Xu Binghe

Abstract excerpt

BACKGROUND: Urinary cell-free deoxyribonucleic acid (DNA) (ucfDNA) holds promise as a biomarker; however, its potential remains largely unexplored. We examined the fragmentation pattern of ucfDNA and identified somatic mutations within urine samples from metastatic breast cancer (MBC) patients. METHODS: Urine and blood specimens were collected before treatment from 45 MBC patients and posttreatment urine samples...

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PMID: 38454812
DOI: 10.4103/jcrt.jcrt_1359_23

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