Comprehensive analysis of germline drivers in endometrial cancer.

doi:10.1093/jnci/djad016

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Comprehensive analysis of germline drivers in endometrial cancer.

Journal of the National Cancer Institute - 8 May 2023

Gordhandas Sushmita, Rios-Doria Eric, Cadoo Karen A, Catchings Amanda, Maio Anna, Kemel Yelena, Sheehan Margaret, Ranganathan Megha, Green Dina, Aryamvally Anjali, Arnold Angela G, Salo-Mullen Erin, Manning-Geist Beryl, Sia Tiffany, Selenica Pier, Da Cruz Paula Arnaud, Vanderbilt Chad, Misyura Maksym, Leitao Mario M, Mueller Jennifer J, Makker Vicky, Rubinstein Maria, Friedman Claire F, Zhou Qin, Iasonos Alexia, Latham Alicia, Carlo Maria I, Murciano-Goroff Yonina R, Will Marie, Walsh Michael F, Issa Bhaloo Shirin, Ellenson Lora H, Ceyhan-Birsoy Ozge, Berger Michael F, Robson Mark E, Abu-Rustum Nadeem, Aghajanian Carol, Offit Kenneth, Stadler Zsofia, Weigelt Britta, Mandelker Diana L, Liu Ying L

Abstract excerpt

BACKGROUND: We sought to determine the prevalence of germline pathogenic variants (gPVs) in unselected patients with endometrial cancer (EC), define biallelic gPVs within tumors, and describe their associations with clinicopathologic features. METHODS: Germline assessment of at least 76 cancer predisposition genes was performed in patients with EC undergoing clinical tumor-normal Memorial Sloan...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microsatellite Instability

Share to Cancer Genomics and Diagnostics

Share to Endometrial and Cervical Cancer Treatments

Share to Endometrial Neoplasms

Share to Genetic factors in colorectal cancer

Share to Genetic Predisposition to Disease

Share to Germ-Line Mutation

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 36744932
DOI: 10.1093/jnci/djad016
PMCID: PMC10165491

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive analysis of germline drivers in endometrial cancer.PMID 36744932Read ↗

Pathogenic germline variants in patients with endometrial cancer of diverse ancestrySemantic proximity Read ↗

The mutational landscape of endometrial cancer.Semantic proximity Read ↗

Mutations in cancer-relevant genes are ubiquitous in histologically normal endometrial tissue.Semantic proximity Read ↗

From Genes to Clinical Practice: Exploring the Genomic Underpinnings of Endometrial CancerSemantic proximity Read ↗

Prevalence and Landscape of Pathogenic or Likely Pathogenic Germline Variants and Their Association With Somatic Phenotype in Unselected Chinese Patients With Gynecologic Cancers.Semantic proximity Read ↗

Whole genome sequencing of endometrial cancer identifies novel subgroups, drivers, and actionable alterationsSemantic proximity Read ↗

Up-Front Multigene Panel Testing for Cancer Susceptibility in Patients With Newly Diagnosed Endometrial Cancer: A Multicenter Prospective Study.Semantic proximity Read ↗

From Genes to Clinical Practice: Exploring the Genomic Underpinnings of Endometrial CancerSemantic proximity Read ↗

Upfront Multigene Panel Testing for Cancer Susceptibility in Newly Diagnosed Endometrial Cancer Patients: A Prospective Cohort StudySemantic proximity Read ↗

Endometrial Cancers in BRCA1 or BRCA2 Germline Mutation Carriers: Assessment of Homologous Recombination DNA Repair DefectsSemantic proximity Read ↗

Genome-wide mutation analysis in precancerous lesions of endometrial carcinoma.Semantic proximity Read ↗

Germline multigene panel testing of patients with endometrial cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.