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Article

Insights into non-informative results from non-invasive prenatal screening through gestational age, maternal BMI, and age analyses

7 Mar 2024

Abstract excerpt

The discovery of cell-free fetal DNA fragments in the maternal plasma initiated a novel testing method in prenatal care, called non-invasive prenatal screening (NIPS). One of the limitations of NIPS is the necessity for a sufficient proportion of fetal fragments in the analyzed circulating DNA mixture (fetal fraction), otherwise, the sample is uninterpretable. We present the effect of gestational age, maternal...

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PMID: 38452118
DOI: 10.1371/journal.pone.0280858

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