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Factors affecting cell-free DNA fetal fraction: statistical analysis of 13,661 maternal plasmas for non-invasive prenatal screening

1 Dec 2019

Abstract excerpt

Abstract Background The identification of cell-free fetal DNA (cffDNA) facilitated non-invasive prenatal screening (NIPS) through analysis of cffDNA in maternal plasma. However, challenges regarding its clinical implementation become apparent. Factors affecting fetal fraction should be clarified to guide its clinical application. Results A total of 13,661 pregnant subjects with singleton pregnancies who undertook...

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Share to Fetal and Pediatric Neurological Disorders
Share to Pregnancy and preeclampsia studies
Share to Prenatal Screening and Diagnostics

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PMID: 31801621
DOI: 10.1186/s40246-019-0244-0

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