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Article

Comparing methods for fetal fraction determination and quality control of NIPT samples

31 May 2017

Abstract excerpt

OBJECTIVE: To compare available analysis methods for determining fetal fraction on single read next generation sequencing data. This is important as the performance of non-invasive prenatal testing (NIPT) procedures depends on the fraction of fetal DNA. METHODS: We tested six different methods for the detection of fetal fraction in NIPT samples. The same clinically obtained data were used for all methods,...

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PMID: 28561435
DOI: 10.1002/pd.5079

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