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Article

High-throughput fetal fraction amplification increases analytical performance of noninvasive prenatal screening

14 Nov 2020

Abstract excerpt

PURPOSE: The percentage of a maternal cell-free DNA (cfDNA) sample that is fetal-derived (the fetal fraction; FF) is a key driver of the sensitivity and specificity of noninvasive prenatal screening (NIPS). On certain NIPS platforms, >20% of women with high body mass index (and >5% overall) receive a test failure due to low FF (<4%). METHODS: A scalable fetal fraction amplification (FFA) technology was...

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Share to Fetal and Pediatric Neurological Disorders
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Share to Prenatal Screening and Diagnostics

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PMID: 33190143
DOI: 10.1038/s41436-020-01009-5

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