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Article

The ALK receptor in sympathetic neuron development and neuroblastoma.

Cell and tissue research - 1 May 2018

Janoueix-Lerosey Isabelle, Lopez-Delisle Lucille, Delattre Olivier, Rohrer Hermann

Abstract excerpt

The ALK gene encodes a tyrosine kinase receptor characterized by an expression pattern mainly restricted to the developing central and peripheral nervous systems. In 2008, the discovery of ALK activating mutations in neuroblastoma, a tumor of the sympathetic nervous system, represented a breakthrough in the understanding of the pathogenesis of this pediatric cancer and established mutated ALK as a tractable...

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Source

Identifiers

PMID: 29374774
DOI: 10.1007/s00441-017-2784-8

Genes

ALK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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