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Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma

29 Sept 2023

Abstract excerpt

pluripotent stem cells and single-cell RNA sequencing to recapitulate the molecular events during sympathoadrenal development. We provide a detailed map of dynamically regulated transcriptomes during sympathoblast formation and illustrate the power of this model to study early events of the development of human neuroblastoma, identifying a distinct subpopulation of cell marked by SOX2 expression in developing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38222111
DOI: 10.1016/j.isci.2023.108096

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