Catalytic activity in vitro of the human protein kinase ASK1 mutants: Experimental and molecular simulation study.

Abstract excerpt

Kinases have become an important class of targets for drug discovery since the milestone approval of imatinib in 2001. Although a great success has been achieved for targeting kinases with over 70 inhibitors approved by the FDA, it is inevitable that drug resistance would emerge during treatment. Thus, assessment of the kinase mutations is an essential issue for the development of the next generation inhibitors....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Molecular Dynamics Simulation
• Share to Mutation