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Article

Targeting the hedgehog pathway to treat basal cell carcinoma.

Journal of drugs in dermatology : JDD - 1 May 2013

Geeraert Pieter, Williams Jonathan S, Brownell Isaac

Abstract excerpt

The discovery of mutations that activate hedgehog (Hh) signaling in basal cell carcinoma (BCC) and other cancers has spurred the development of small molecule inhibitors that target the Hh pathway. High-throughput screens have identified a number of drug candidates that antagonize smoothened (SMO), an essential protein in the Hh signaling pathway. Clinical studies of the oral SMO inhibitor vismodegib (GDC-0449)...

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Identifiers

PMID: 23652945

Genes

SMO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Novel Approaches in Non-Melanoma Skin Cancers—A Focus on Hedgehog Pathway in Basal Cell Carcinoma (BCC)Semantic proximity Read ↗

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