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Article

Targeting the hedgehog pathway to treat basal cell carcinoma.

Journal of drugs in dermatology : JDD - 1 May 2013

Geeraert Pieter, Williams Jonathan S, Brownell Isaac

Abstract excerpt

The discovery of mutations that activate hedgehog (Hh) signaling in basal cell carcinoma (BCC) and other cancers has spurred the development of small molecule inhibitors that target the Hh pathway. High-throughput screens have identified a number of drug candidates that antagonize smoothened (SMO...

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PMID: 23652945

Genes

SMO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23652945-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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