Article
Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function.
Biological psychiatry - 1 Jul 2009
Hariri Ahmad R, Gorka Adam, Hyde Luke W, Kimak Mark, Halder Indrani, Ducci Francesca, Ferrell Robert E, Goldman David, Manuck Stephen B
Abstract excerpt
BACKGROUND: Fatty acid amide hydrolase (FAAH) is a key enzyme in regulating endocannabinoid (eCB) signaling. A common single nucleotide polymorphism (C385A) in the human FAAH gene has been associated with increased risk for addiction and obesity. METHODS: Using imaging genetics in 82 healthy adult volunteers, we examined the effects of FAAH C385A on threat- and reward-related human brain function. RESULTS:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.