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Article

Genetic variation in endocannabinoid signaling is associated with differential network-level functional connectivity in youth.

Journal of neuroscience research - 1 Mar 2022

Sisk Lucinda M, Rapuano Kristina M, Conley May I, Greene Abigail S, Horien Corey, Rosenberg Monica D, Scheinost Dustin, Constable R Todd, Glatt Charles E, Casey B J, Gee Dylan G

Abstract excerpt

The endocannabinoid system is an important regulator of emotional responses such as fear, and a number of studies have implicated endocannabinoid signaling in anxiety. The fatty acid amide hydrolase (FAAH) C385A polymorphism, which is associated with enhanced endocannabinoid signaling in the brain, has been identified across species as a potential protective factor from anxiety. In particular, adults with the...

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PMID: 34496065
DOI: 10.1002/jnr.24946
PMCID: PMC8866205

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