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A Metabolome-Wide Mendelian Randomization Study Identifies Dysregulated Arachidonic Acid Synthesis as a Potential Causal Risk Factor for Bipolar Disorder.

Biological psychiatry - 15 Sept 2024

Stacey David, Benyamin Beben, Lee S Hong, Hyppönen Elina

Abstract excerpt

BACKGROUND: Bipolar disorder (BPD) is a debilitating mood disorder with an unclear etiology. A better understanding of the underlying pathophysiological mechanisms will help to identify novel targets for improved treatment options and prevention strategies. In this metabolome-wide Mendelian randomization study, we screened for metabolites that may have a causal role in BPD. METHODS: We tested a total of 913...

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Identifiers

PMID: 38401803
DOI: 10.1016/j.biopsych.2024.02.1005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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