Article
Assessment of causal relationships between omega-3 and omega-6 polyunsaturated fatty acids in bipolar disorder: a 2-sample bidirectional mendelian randomization study.
Food & function - 3 Jul 2023
Zhang Min, Li Xinwei, Dong Lin, Jin Mengdi, Xie Mengtong, Jia Ningning, Liu Yane, Xue Fengyu, Li Weizhen, Yang Yuqing, Song Haideng, Lu Qingxing, Jiang Lintong, Yu Qiong
Abstract excerpt
Omega-3 fatty acids may be protective against bipolar disorder (BD), whereas omega-6 fatty acids and an increased omega-6:omega-3 ratio may increase the risk of BD. This causal relationship has not yet been established. We attempted to prove the existence of these causal relationships in this study. Datasets on omega-3, omega-6, and omega-6:omega-3 ratios were obtained from the UK Biobank. The EBI database was...
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