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Article

Association of plasma arachidonic acid levels with a bipolar disorder and the effects of a FADS gene variant.

Translational psychiatry - 14 Oct 2024

Ashizawa Takuma, Saito Takeo, Okochi Tomo, Ninomiya Kohei, Ito Kenta, Aoki Rei, Ikeda Masashi, Iwata Nakao

Abstract excerpt

Recent genome-wide association studies (GWASs) have identified fatty acid desaturase (FADS) genes, which code key enzymes involved in polyunsaturated fatty acid (PUFA) desaturation as susceptibility genes for bipolar disorder (BD). Several quantitative changes in PUFAs suggest their involvement in BD pathogenesis. Therefore, this study aimed to clarify the relationship between BD and PUFAs by conducting...

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Identifiers

PMID: 39396983
DOI: 10.1038/s41398-024-03141-1
PMCID: PMC11471766

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