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Clinical and genetic contributions to medical comorbidity in bipolar disorder: a study using electronic health records-linked biobank data.

Molecular psychiatry - 1 Sept 2024

Sanchez-Ruiz Jorge A, Coombes Brandon J, Pazdernik Vanessa M, Melhuish Beaupre Lindsay M, Jenkins Greg D, Pendegraft Richard S, Batzler Anthony, Ozerdem Aysegul, McElroy Susan L, Gardea-Resendez Manuel A, Cuellar-Barboza Alfredo B, Prieto Miguel L, Frye Mark A, Biernacka Joanna M

Abstract excerpt

Bipolar disorder is a chronic and complex polygenic disease with high rates of comorbidity. However, the independent contribution of either diagnosis or genetic risk of bipolar disorder to the medical comorbidity profile of individuals with the disease remains unresolved. Here, we conducted a multi-step phenome-wide association study (PheWAS) of bipolar disorder using phenomes derived from the electronic health...

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Identifiers

PMID: 38548982
DOI: 10.1038/s41380-024-02530-8
PMCID: PMC11544602

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