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Article

Evidence that genes involved in hedgehog signaling are associated with both bipolar disorder and high BMI.

Translational psychiatry - 21 Nov 2019

Pisanu Claudia, Williams Michael J, Ciuculete Diana M, Olivo Gaia, Del Zompo Maria, Squassina Alessio, Schiöth Helgi B

Abstract excerpt

Patients with bipolar disorder (BD) show higher frequency of obesity and type 2 diabetes (T2D), but the underlying genetic determinants and molecular pathways are not well studied. Using large publicly available datasets, we (1) conducted a gene-based analysis using MAGMA to identify genes associated with BD and body mass index (BMI) or T2D and investigated their functional enrichment; and (2) performed two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 31754094
DOI: 10.1038/s41398-019-0652-x
PMCID: PMC6872724

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