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Article

Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked Parkinson's disease phenotypes in vivo and in cell models.

Journal of biomedical science - 23 Feb 2024

Tio Murni, Wen Rujing, Choo Cai Ning, Tan Jian Bin, Chua Aaron, Xiao Bin, Sundaram Jeyapriya Rajameenakshi, Chan Christine Hui Shan, Tan Eng-King

Abstract excerpt

BACKGROUND: Mutations in CHCHD2 have been linked to Parkinson's disease, however, their exact pathophysiologic roles are unclear. The p32 protein has been suggested to interact with CHCHD2, however, the physiological functions of such interaction in the context of PD have not been clarified. METHODS: Interaction between CHCHD2 and p32 was confirmed by co-immunoprecipitation experiments. We studied the effect of...

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Identifiers

PMID: 38395904
DOI: 10.1186/s12929-024-01010-z
PMCID: PMC10893700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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