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Article

CHCHD2 accumulates in distressed mitochondria and facilitates oligomerization of CHCHD10.

Human molecular genetics - 15 Nov 2018

Huang Xiaoping, Wu Beverly P, Nguyen Diana, Liu Yi-Ting, Marani Melika, Hench Jürgen, Bénit Paule, Kozjak-Pavlovic Vera, Rustin Pierre, Frank Stephan, Narendra Derek P

Abstract excerpt

Mutations in paralogous mitochondrial proteins CHCHD2 and CHCHD10 cause autosomal dominant Parkinson Disease (PD) and Amyotrophic Lateral Sclerosis/Frontotemporal Dementia (ALS/FTD), respectively. Using newly generated CHCHD2, CHCHD10 and CHCHD2/10 double knockout cell lines, we find that the proteins are partially functionally redundant, similarly distributed throughout the mitochondrial cristae, and form...

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Source

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Identifiers

PMID: 30084972
DOI: 10.1093/hmg/ddy270
PMCID: PMC6216204

Genes

CHCHD2
CHCHD10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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