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Article

CHCHD2 links mitochondrial dysfunction and α-synuclein misfolding in Parkinson's disease.

Trends in neurosciences - 1 Mar 2026

Narendra Derek, Ryan Brent J

Abstract excerpt

Parkinson's disease comprises multiple biological subtypes and a heterogeneous clinical course. A recent study by Liao et al. identifies CHCHD2 mutations as a mitochondrial entry point that links metabolic dysfunction to α-synuclein pathology. These findings highlight how rare sporadiclike monogenic forms of Parkinson's disease may inform mechanistic and therapeutic stratification.

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Source

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Identifiers

PMID: 41763921
DOI: 10.1016/j.tins.2026.02.002
PMCID: PMC13328052

Genes

CHCHD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolismSemantic proximity Read ↗

Early-onset Parkinson disease caused by a mutation in CHCHD2 and mitochondrial dysfunctionSemantic proximity Read ↗

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PARK Genes Link Mitochondrial Dysfunction and Alpha-Synuclein Pathology in Sporadic Parkinson’s DiseaseSemantic proximity Read ↗

Mitochondrial CHCHD2 and CHCHD10: Roles in Neurological Diseases and Therapeutic ImplicationsSemantic proximity Read ↗

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