Article

CHCHD2 mutant mice display mitochondrial protein accumulation and disrupted energy metabolism

2024-09-01

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the mitochondrial cristae protein CHCHD2 lead to a late-onset autosomal dominant form of Parkinson’s disease (PD) which closely resembles idiopathic PD, providing the opportunity to gain new insights into the mechanisms of mitochondrial dysfunction contributing to PD. To begin to address this, we used CRISPR genome-editing to generate CHCHD2 T61I point mutant mice. CHCHD2 T61I mice...

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Literature Corpus work: 74cc970b-b29d-57bb-980c-95903438afa8
DOI: 10.1101/2024.08.30.610586

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