Article
Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.
Nature communications - 7 Jun 2017
Meng Hongrui, Yamashita Chikara, Shiba-Fukushima Kahori, Inoshita Tsuyoshi, Funayama Manabu, Sato Shigeto, Hatta Tomohisa, Natsume Tohru, Umitsu Masataka, Takagi Junichi, Imai Yuzuru, Hattori Nobutaka
Abstract excerpt
Mutations in CHCHD2 have been identified in some Parkinson's disease (PD) cases. To understand the physiological and pathological roles of CHCHD2, we manipulated the expression of CHCHD2 in Drosophila and mammalian cells. The loss of CHCHD2 in Drosophila causes abnormal matrix structures and impaired oxygen respiration in mitochondria, leading to oxidative stress, dopaminergic neuron loss and motor dysfunction...
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