Article

Comprehensive analysis of potential immunotherapy genomic biomarkers in 1,000 Chinese patients with cancer

2018-07-10

Abstract excerpt

<h4>Background</h4> Tumor mutation burden (TMB), DNA mismatch repair deficiency (dMMR), microsatellite instability (MSI), and PD-L1 amplification (PD-L1 AMP) may predict the efficacy of PD-1/PD-L1 blockade. In this study, we aimed to characterize the distributions of these biomarkers in over 1,000 Chinese patients with cancer. <h4>Methods</h4> TMB, MSI, dMMR, and PD-L1 AMP were determined based on whole-exome se...

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Literature Corpus work: 7756bf34-523c-55f8-9cc6-add9fd67a839
DOI: 10.1101/366062

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