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Article

Generation of anti-GD2 CAR macrophages from human pluripotent stem cells for cancer immunotherapies

12 Jan 2023

Abstract excerpt

Macrophages armed with chimeric antigen receptors (CARs) provide a potent new option for treating solid tumors. However, genetic engineering and scalable production of somatic macrophages remains significant challenges. Here, we used CRISPR-Cas9 gene editing methods to integrate an anti-GD2 CAR into the AAVS1 locus of human pluripotent stem cells (hPSCs). We then established a serum- and feeder-free...

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PMID: 36638788
DOI: 10.1016/j.stemcr.2022.12.012

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