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Cellular senescence: Neither irreversible nor reversible

7 Feb 2024

Abstract excerpt

Cellular senescence is a critical stress response program implicated in embryonic development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate cell-cycle exit mechanism. In analogy to replicative exhaustion of telomere-eroded cells, premature types of senescence-referring to oncogene-, therapy-, or virus-induced senescence-are widely considered irreversible growth arrest states as...

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PMID: 38385946
DOI: 10.1084/jem.20232136

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