Cellular senescence: a reflection of normal growth control, differentiation, or aging?

doi:10.1002/jcb.240450205

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Article

Cellular senescence: a reflection of normal growth control, differentiation, or aging?

Journal of cellular biochemistry - 1 Feb 1991

Peacocke M, Campisi J

Abstract excerpt

Normal cells, with few exceptions, cannot proliferate indefinitely. Cell populations--in vivo and in culture--generally undergo only a limited number of doublings before proliferation invariably and irreversibly ceases. This process has been termed the finite lifespan phenotype or cellular senescence. There is long-standing, albeit indirect, evidence that cellular senescence plays an important role in complex...

Topics

Adult
Aged
Aged, 80 and over
Aging
Animals
Cell Differentiation
Cell Division
Cell Fusion
Cell Survival
Cell Transformation, Neoplastic
Cells, Cultured
Eukaryotic Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fibroblasts

Gene Expression Regulation

Humans

Middle Aged

Models, Biological

Phenotype

Source

Open in PubMed

Identifiers

PMID: 2055943
DOI: 10.1002/jcb.240450205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2055943-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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