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Article

Mutational patterns in therapy-related acute lymphoblastic leukemia subgroups: one step closer to unveiling the genetic odyssey.

Leukemia & lymphoma - 1 Jun 2024

Hofer Kevin D, Bühler Marco M, Roncador Marco, Rechsteiner Markus, Maggio Ewerton M, Tchinda Joëlle, Schanz Urs, Haralambieva Eugenia, Widmer Corinne C

Abstract excerpt

There is increasing evidence that therapy-related acute lymphoblastic leukemia (trALL) resulting from chemo- and/or radiotherapy represents a distinct entity. However, apart from KMT2A rearrangements, which have been repeatedly reported in this subgroup, the relevance of other aberrations remains controversial due to divergent study results and sparse molecular analyses. Within our ALL patient cohort, 15%...

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Source

Identifiers

PMID: 38385617
DOI: 10.1080/10428194.2024.2315171

Genes

KMT2A
CDKN2A
DNMT3A
KMT2D
KRAS
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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