Article
Therapy-related acute lymphoblastic leukemia is a distinct entity with adverse genetic features and clinical outcomes.
Blood advances - 23 Dec 2019
Saygin Caner, Kishtagari Ashwin, Cassaday Ryan D, Reizine Natalie, Yurkiewicz Ilana, Liedtke Michaela, Stock Wendy, Larson Richard A, Levine Ross L, Tallman Martin S, Park Jae H, Kerr Cassandra, Przychodzen Bartlomiej, Sekeres Mikkael A, Kalaycio Matt E, Carraway Hetty E, Hamilton Betty K, Sobecks Ronald, Gerds Aaron, Mukherjee Sudipto, Nazha Aziz, Maciejewski Jaroslaw P, Advani Anjali S
Abstract excerpt
Patients with therapy-related acute lymphoblastic leukemia (t-ALL) represent a small subset of acute lymphoblastic leukemia (ALL) patients who received genotoxic therapy (ie, chemotherapy or radiation) for a prior malignancy. These patients should be distinguished from patients with de novo ALL (dn-ALL) and ALL patients who have a history of prior malignancy but have not received cytotoxic therapies in the past...
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