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Article

Effect of Age, Comedications, and CYP3A4/5 Polymorphisms on Perampanel Exposure in Chinese Pediatric Patients With Epilepsy.

Journal of clinical pharmacology - 1 Jun 2024

Wang Huijuan, Wang Junyan, Lin Bin, Zhang Huifen, Sun Yangyang, Wu Yuanyuan, Ye Weifeng, Miao Jing

Abstract excerpt

Perampanel (PER) is a new type of antiseizure medication used for partial or generalized seizures. However, the plasma concentration shows obvious individual variability in children. The present study aims to ascertain the effect of age, comedications, and cytochrome P450 (CYP) 3A4/5 polymorphisms on PER exposure in Chinese pediatric patients with epilepsy. Clinical data were retrospectively collected in a...

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Source

Identifiers

PMID: 38381330
DOI: 10.1002/jcph.2415

Genes

CYP3A5
CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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