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Article

Population pharmacokinetics of oxcarbazepine active metabolite in Chinese children with epilepsy.

European journal of pediatrics - 1 Oct 2023

Li Xingmeng, Wei Shifeng, Wu Han, Zhang Qiang, Zhao Zhigang, Mei Shenghui, Feng Weixing, Wu Yun

Abstract excerpt

Oxcarbazepine (OXC) is an antiepileptic drug whose efficacy is largely attributed to its monohydroxy derivative metabolite (MHD). Nevertheless, there exists significant inter-individual variability in both the pharmacokinetics and therapeutic response of this drug. The objective of this study is to explore the impact of patients' characteristics and genetic variants on MHD clearance in a population...

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Identifiers

PMID: 37493972
DOI: 10.1007/s00431-023-05092-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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