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Article

Impact of ABCC2 1249G>A and -24C>T Polymorphisms on Lacosamide Efficacy and Plasma Concentrations in Uygur Pediatric Patients With Epilepsy in China.

Therapeutic drug monitoring - 1 Feb 2023

Zhao Ting, Li Hong-Jian, Zhang Hui-Lan, Feng Jie, Yu Jing, Wang Ting-Ting, Sun Yan, Yu Lu-Hai

Abstract excerpt

PURPOSE: We aimed to evaluate the effect of the ABCC2 1249G>A (rs2273697) and -24C>T (rs717620) polymorphisms on lacosamide (LCM) plasma concentrations and the efficacy of LCM in Uygur pediatric patients with epilepsy. METHODS: We analyzed 231 pediatric patients with epilepsy, among which 166 were considered to be LCM responsive. For drug assays, 2-3 mL of venous blood was collected from each patient just before...

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Identifiers

PMID: 36253887
DOI: 10.1097/FTD.0000000000001003
PMCID: PMC9819208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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