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Article

Effects of CYP2C19 and CYP2C9 polymorphisms on the efficacy and plasma concentration of lacosamide in pediatric patients with epilepsy in China.

European journal of pediatrics - 10 Dec 2024

Zhao Ting, Li Hong-Jian, Zhang Hui-Lan, Yu Jing, Feng Jie, Cui Long, Sun Ke-Fang, Sun Yan, Yu Lu-Hai

Abstract excerpt

To evaluate the effects of cytochrome P450 family 2 subfamily C member 9 (CYP2C9) and cytochrome P450 family 2 subfamily C member 19 (CYP2C19) polymorphisms on the plasma concentrations, efficacy, and safety of lacosamide (LCM) among pediatric patients with epilepsy. This prospective study was conducted at two institutions. It included 215 pediatric patients with epilepsy who were under LCM. LCM plasma...

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PMID: 39658609
DOI: 10.1007/s00431-024-05897-6

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